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Effect of static load on matrix synthesis rates in the intervertebral disc measured in vitro by a new perfusion technique.

Abstract:

The effect of static loading on matrix synthesis was measured in intact bovine coccygeal discs. The discs were maintained at 37 degrees C in a humid atmosphere and were perfused across their upper and lower surfaces for as long as 8 hours with media containing radioisotopes (3H-proline and 35S-sulphate) via porous filter disks embedded in Perspex (Plexiglas) holders. Static loads were applied to the disc with use of weights. The activity of free, nonincorporated isotope in the centre of the d...

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Publication status:
Published

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Publisher copy:
10.1002/jor.1100130106

Authors


Ohshima, H More by this author
Bergel, DH More by this author
Publisher:
Raven Press Ltd
Journal:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Volume:
13
Issue:
1
Pages:
22-29
Publication date:
1995-01-05
DOI:
EISSN:
1554-527X
ISSN:
0736-0266
URN:
uuid:13d80a46-c44f-4a28-9ab8-685bd461660a
Source identifiers:
433368
Local pid:
pubs:433368

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