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Journal article

A therapeutic vaccine for nicotine dependence: preclinical efficacy, and Phase I safety and immunogenicity.

Abstract:

Nicotine is the principal addictive component in tobacco, and following uptake acts in the central nervous system. The smoking-cessation efforts of most smokers fail because a single slip often delivers sufficient nicotine to the brain to reinstate the drug-seeking behaviour. Blocking nicotine from entering the brain by induction of specific antibodies may be an effective means to prevent such relapses. The hapten nicotine was coupled to virus-like particles (VLP) formed by the coat protein o...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200526285

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Journal:
European journal of immunology
Volume:
35
Issue:
7
Pages:
2031-2040
Publication date:
2005-07-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
469731
Language:
English
Keywords:
Pubs id:
pubs:469731
UUID:
uuid:13d76d51-c62f-4cd2-bba0-597326c395db
Local pid:
pubs:469731
Deposit date:
2014-06-18

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