Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium.

Journal article

Citrobacter rodentium, an attaching-effacing bacterial pathogen, establishes an acute infection of the murine colonic epithelium and induces a mild colitis in immunocompetent mice. This study describes the role of T-cell subsets and B lymphocytes in immunity to C. rodentium. C57Bl/6 mice orally infected with C. rodentium resolved infection within 3 to 4 weeks. Conversely, systemic and colonic tissues of RAG1(-/-) mice orally infected with C. rodentium contained high and sustained pathogen loa...

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Authors: Simmons, C; Clare, S; Ghaem-Maghami, M; Uren, T; Rankin, J

• Publication status: Published
• Journal: Infection and immunity
• Volume: 71
• Issue: 9
• Pages: 5077-5086
• Publication date: 2003-09-01
• DOI: 10.1128/iai.71.9.5077-5086.2003
• EISSN: 1098-5522
• ISSN: 0019-9567
• Language: English
• Keywords: Colon; Virulence; Mice, Knockout; CD4-Positive T-Lymphocytes; Animals; B-Lymphocytes; Genes, RAG-1; Mice; Mice, Inbred C57BL; Antibodies, Bacterial; Male; Adoptive Transfer; Immunocompetence; Citrobacter freundii; Enterobacteriaceae Infections; Lymphocyte Depletion; Antigens, Bacterial; Female; Bacterial Proteins; Immunocompromised Host