Developmentally acquired PKA localisation in mouse oocytes and embryos.

Journal article

Localisation of Protein Kinase A (PKA) by A-Kinase Anchoring Proteins (AKAPs) is known to coordinate localised signalling complexes that target cAMP-mediated signalling to specific cellular sub-domains. The cAMP PKA signalling pathway is implicated in both meiotic arrest and meiotic resumption, thus spatio-temporal changes in PKA localisation during development may determine the oocytes response to changes in cAMP. In this study we aim to establish whether changes in PKA localisation occur du...

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Authors: Webb, R; Tinworth, L; Thomas, G; Zaccolo, M; Carroll, J

• Journal: Developmental biology
• Volume: 317
• Issue: 1
• Pages: 36-45
• Publication date: 2008-05-01
• DOI: 10.1016/j.ydbio.2008.01.045
• EISSN: 1095-564X
• ISSN: 0012-1606
• Language: English
• Keywords: Cyclic AMP-Dependent Protein Kinases; A Kinase Anchor Proteins; Animals; Mitochondria; Mice; Female; Meiosis; Oocytes; Embryo, Mammalian; Fertilization; Pregnancy