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Journal article

The relationship between the chemistry and biological activity of the bisphosphonates.

Abstract:

The ability of bisphosphonates ((HO)(2)P(O)CR(1)R(2)P(O)(OH)(2)) to inhibit bone resorption has been known since the 1960s, but it is only recently that a detailed molecular understanding of the relationship between chemical structures and biological activity has begun to emerge. The early development of chemistry in this area was largely empirical and based on modifying R(2) groups in a variety of ways. Apart from the general ability of bisphosphonates to chelate Ca(2+) and thus target the c...

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Publication status:
Published

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Publisher copy:
10.1016/j.bone.2011.03.774

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Journal:
Bone
Volume:
49
Issue:
1
Pages:
20-33
Publication date:
2011-07-01
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
Source identifiers:
134946
Language:
English
Keywords:
Pubs id:
pubs:134946
UUID:
uuid:13d09d5c-4f89-4177-bfe0-21a6fd84f752
Local pid:
pubs:134946
Deposit date:
2012-12-19

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