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Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele.

Abstract:

BACKGROUND: Functional magnetic resonance imaging (MRI) studies have shown that APOE ε2- and ε4-carriers have similar patterns of blood-oxygenation-level-dependent (BOLD) activation suggesting that we need to look beyond the BOLD signal to link APOE's effect on the brain to Alzheimer's disease (AD)-risk. METHODS: We evaluated APOE-related differences in BOLD activation in response to a memory task, cerebrovascular reactivity using a CO2-inhalation challenge (CO2-CVR), and the potential contri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jalz.2014.05.1755

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Germuska, M More by this author
Tunbridge, EM More by this author
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Publisher:
Elsevier Publisher's website
Journal:
Alzheimer's and Dementia Journal website
Volume:
11
Issue:
6
Pages:
648–657.e1
Publication date:
2015-06-05
DOI:
EISSN:
1552-5279
ISSN:
1552-5260
URN:
uuid:13c4b390-4a52-45fb-a71f-909a58e15963
Source identifiers:
482496
Local pid:
pubs:482496

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