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Abundant glial alpha-synuclein pathology in a case without overt clinical symptoms

Abstract:

Screening of 1,800 brains with alpha-synuclein (alphaS) immunohistochemistry revealed five cases with abundant glial cytoplasmic inclusions (GCIs) within the white matter of the brainstem. Surprisingly, retrospective clinical assessment showed that one of these subjects did not fulfil the currently recommended clinical consensus criteria for the multiple system atrophy (MSA). One of the hallmark lesions of MSA, alphaS-positive GCIs, were widespread and abundant in this atypical case that none...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.5414/NPP26276

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More from this funder
Grant:
QLRI-CT-2000-00066
LSHM-CT-2004-503039
Finnish Cultural Foundation More from this funder
Publisher:
Dustri-Verlag Publisher's website
Journal:
Clinical Neuropathology Journal website
Publication date:
2007-11-01
DOI:
ISSN:
0722-5091
Source identifiers:
579212
Keywords:
Pubs id:
pubs:579212
UUID:
uuid:13be295e-b73e-43d6-9bb8-ca9dd1c62c89
Local pid:
pubs:579212
Deposit date:
2015-12-09

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