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Journal article

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

Abstract:

Polycomb Repressor Complexes (PRCs) are important regulators of embryogenesis. In embryonic stem (ES) cells many genes that regulate subsequent stages in development are enriched at their promoters for PRC1, PRC2 and Ser 5-phosphorylated RNA Polymerase II (RNAP), and contain domains of 'bivalent' chromatin (enriched for H3K4me3; histone H3 di- or trimethylated at Lys 4 and H3K27me3; histone H3 trimethylated at Lys 27). Loss of individual PRC components in ES cells can lead to gene de-repressi...

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Publication status:
Published

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Publisher copy:
10.1038/ncb2065

Authors


Landeira, D More by this author
Dvorkina, M More by this author
Mazzarella, L More by this author
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Journal:
Nature cell biology
Volume:
12
Issue:
6
Pages:
618-624
Publication date:
2010-06-05
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
URN:
uuid:13af4fa4-7958-4144-bf5f-7af6ea113786
Source identifiers:
99970
Local pid:
pubs:99970

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