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Journal article

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

Abstract:

Polycomb Repressor Complexes (PRCs) are important regulators of embryogenesis. In embryonic stem (ES) cells many genes that regulate subsequent stages in development are enriched at their promoters for PRC1, PRC2 and Ser 5-phosphorylated RNA Polymerase II (RNAP), and contain domains of 'bivalent' chromatin (enriched for H3K4me3; histone H3 di- or trimethylated at Lys 4 and H3K27me3; histone H3 trimethylated at Lys 27). Loss of individual PRC components in ES cells can lead to gene de-repressi...

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Publication status:
Published

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Publisher copy:
10.1038/ncb2065

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Journal:
Nature cell biology
Volume:
12
Issue:
6
Pages:
618-624
Publication date:
2010-06-01
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
Source identifiers:
99970
Language:
English
Keywords:
Pubs id:
pubs:99970
UUID:
uuid:13af4fa4-7958-4144-bf5f-7af6ea113786
Local pid:
pubs:99970
Deposit date:
2012-12-19

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