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Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation.

Abstract:

During antigen recognition by T cells different receptors and ligands form a pattern in the intercellular junction called the immunological synapse, which might be involved in T-cell activation. Recently, a synapse assembly model has been proposed, which enables the calculation of the propensity for synapse assembly driven by membrane-constrained protein binding interactions. We bring together model predictions of mature synapse assembly with data on the dependence of T-cell responses on T-ce...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Trends in immunology
Volume:
23
Issue:
10
Pages:
492-499
Publication date:
2002-10-05
DOI:
EISSN:
1471-4981
ISSN:
1471-4906
URN:
uuid:13a927a5-5cf1-43a7-8f40-9dab4ba82ab8
Source identifiers:
482646
Local pid:
pubs:482646

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