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Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.

Abstract:

Atopic or immunoglobulin E (IgE)-mediated diseases include the common disorders of asthma, atopic dermatitis and allergic rhinitis. Chromosome 13q14 shows consistent linkage to atopy and the total serum IgE concentration. We previously identified association between total serum IgE levels and a novel 13q14 microsatellite (USAT24G1; ref. 7) and have now localized the underlying quantitative-trait locus (QTL) in a comprehensive single-nucleotide polymorphism (SNP) map. We found replicated assoc...

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Publication status:
Published

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Publisher copy:
10.1038/ng1166

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Journal:
Nature genetics
Volume:
34
Issue:
2
Pages:
181-186
Publication date:
2003-06-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
54014
Language:
English
Keywords:
Pubs id:
pubs:54014
UUID:
uuid:13a71f3d-65bb-4fb0-b422-766db29a1131
Local pid:
pubs:54014
Deposit date:
2012-12-19

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