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Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

Abstract:

Effective targeted therapy for sepsis requires an understanding of the heterogeneity in the individual host response to infection. We investigated this heterogeneity by defining interindividual variation in the transcriptome of patients with sepsis and related this to outcome and genetic diversity.We assayed peripheral blood leucocyte global gene expression for a prospective discovery cohort of 265 adult patients admitted to UK intensive care units with sepsis due to community-acquired pneumo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/s2213-2600(16)00046-1

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Grant:
FP7/2007-2013-281824
294557
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Grant:
090532/Z/09/Z
074318[JCK],
Publisher:
Elsevier Publisher's website
Journal:
Lancet Respiratory Medicine Journal website
Volume:
4
Issue:
4
Pages:
259-271
Publication date:
2016-01-01
DOI:
EISSN:
2213-2619
ISSN:
2213-2600
Source identifiers:
609353
Language:
English
Pubs id:
pubs:609353
UUID:
uuid:13a6378c-e54b-425b-accc-6c520042471c
Local pid:
pubs:609353
Deposit date:
2016-04-15

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