- Abstract:
-
The advent of hyperpolarized (13)C magnetic resonance (MR) has provided new potential for the real-time visualization of in vivo metabolic processes. The aim of this work was to use hyperpolarized [1-(13)C]pyruvate as a metabolic tracer to assess noninvasively the flux through the mitochondrial enzyme complex pyruvate dehydrogenase (PDH) in the rat heart, by measuring the production of bicarbonate (H(13)CO(3)(-)), a byproduct of the PDH-catalyzed conversion of [1-(13)C]pyruvate to acetyl-CoA....
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.0805953105
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 105
- Issue:
- 33
- Pages:
- 12051-12056
- Publication date:
- 2008-08-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:139abdb0-bcc9-4a47-8614-87a3b7f8502e
- Source identifiers:
-
106391
- Local pid:
- pubs:106391
- Copyright date:
- 2008
Journal article
In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance.
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