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In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance.

Abstract:

The advent of hyperpolarized (13)C magnetic resonance (MR) has provided new potential for the real-time visualization of in vivo metabolic processes. The aim of this work was to use hyperpolarized [1-(13)C]pyruvate as a metabolic tracer to assess noninvasively the flux through the mitochondrial enzyme complex pyruvate dehydrogenase (PDH) in the rat heart, by measuring the production of bicarbonate (H(13)CO(3)(-)), a byproduct of the PDH-catalyzed conversion of [1-(13)C]pyruvate to acetyl-CoA....

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0805953105

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
105
Issue:
33
Pages:
12051-12056
Publication date:
2008-08-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:139abdb0-bcc9-4a47-8614-87a3b7f8502e
Source identifiers:
106391
Local pid:
pubs:106391

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