Harnessing pandemonium: the clinical implications of tumor heterogeneity in ovarian cancer

Journal article

Abstract:: Heterogeneity has emerged as a key feature of ovarian cancer between different ovarian cancer subtypes; within single ovarian cancer subtypes; and within individual patient tumors. At the genomic level, with the advent of ultra-deep sequencing technologies alongside RNA-Seq, epigenomics, and proteomics, the complexity surrounding heterogeneity has deepened. Here, we summarize the emerging understanding of heterogeneity in cancer as a whole and the key discoveries in this area relating to ovarian cancer. We explore the therapeutic limitations and possibilities posed by heterogeneity and how these will influence the future of ovarian cancer treatment and research.

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Keywords:: HGSOC

ITH

clonal evolution

diversity

tumor evolution

chemotherapy resistance

ovarian cancer

heterogeneity
Pubs id:: pubs:571065
UUID:: uuid:1393d5f4-32e1-40e5-b618-1636d7b2d9ba
Local pid:: pubs:571065
Source identifiers:: 571065
Deposit date:: 2015-10-19
ARK identifier:: ark:/29072/ora_1393d5f432e140e5b6181636d7b2d9ba

Copyright holder:: Sarah P. Blagden
Notes:: Copyright © 2015 Blagden. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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