Journal article
Hanessian-Hullar reaction in the synthesis of highly substituted trans-3,4-dihydroxypyrrolidines: rhamnulose iminosugar mimics inhibit alpha-glucosidase
- Abstract:
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The key step in the syntheses of highly substituted trans-3,4-dihydroxypyrrolidines is introduction of bromide by stereospecific and regiospecific Hanessian-Hullar reactions; benzylidene lactones of l-rhamnonolactone and 6-deoxy-this should be small unnpercase d not l why can I not correct this-gulonolactone allow introduction of N at C2 with inversion or retention of configuration. Initially a protecting group, the benzylidene acetal then provides a bromide at C5 to allow formation of the py...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Accepted manuscript, pdf, 1.3MB, Terms of use)
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- Publisher copy:
- 10.1016/j.tet.2019.130758
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Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- Tetrahedron More from this journal
- Volume:
- 76
- Issue:
- 1
- Article number:
- 130758
- Publication date:
- 2019-11-06
- Acceptance date:
- 2019-10-31
- DOI:
- ISSN:
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0040-4020
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:1069071
- UUID:
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uuid:13916d00-f78c-4953-91b8-36c9e2081c63
- Local pid:
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pubs:1069071
- Source identifiers:
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1069071
- Deposit date:
-
2019-11-01
Terms of use
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2019
- Rights statement:
- © 2019 Elsevier Ltd. All rights reserved.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.tet.2019.130758
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