Diagnostic accuracy of NS1 ELISA and lateral flow rapid tests for dengue sensitivity, specificity and relationship to viraemia and antibody responses.

Journal article

BACKGROUND: Dengue is a public health problem in many countries. Rapid diagnosis of dengue can assist patient triage and management. Detection of the dengue viral protein, NS1, represents a new approach to dengue diagnosis. METHODOLOGY/PRINCIPAL FINDINGS: The sensitivity and specificity of the Platelia NS1 ELISA assay and an NS1 lateral flow rapid test (LFRT) were compared against a gold standard reference diagnostic algorithm in 138 Vietnamese children and adults. Overall, the Platelia NS1 ...

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Authors: Hang, V; Nguyet, N; Trung, D; Tricou, V; Yoksan, S

• Publication status: Published
• Journal: PLoS neglected tropical diseases
• Volume: 3
• Issue: 1
• Pages: e360
• Publication date: 2009-01-01
• DOI: 10.1371/journal.pntd.0000360
• EISSN: 1935-2735
• ISSN: 1935-2727
• Language: English
• Keywords: Enzyme-Linked Immunosorbent Assay; Female; Viremia; Adult; Dengue; Dengue Virus; Male; Antibodies, Viral; Early Diagnosis; Adolescent; Viral Nonstructural Proteins; Reagent Kits, Diagnostic; Antibody Formation; Vietnam; Sensitivity and Specificity; Child; Humans; Viral Load; Child, Preschool