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Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene and arterial oxygen saturation at high altitude.

Abstract:

There is a significant genetic influence on arterial oxygen saturation (Sa(O(2))) in high-altitude (HA) residents. It is not known whether this is true of lowlanders ascending to HA. The I allele of the angiotensin-converting enzyme (ACE) gene is associated with low ACE activity and elite endurance performance. An excess of the I allele has also been reported in South American natives living over 3,000 m and among elite HA mountaineers who demonstrate extreme endurance in a hypoxic environmen...

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Publication status:
Published

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Publisher copy:
10.1164/rccm.2103060

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics, Biomedical Research Centre
Collier, DJ More by this author
Jamshidi, Y More by this author
Vassiliou, V More by this author
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Journal:
American journal of respiratory and critical care medicine
Volume:
166
Issue:
3
Pages:
362-366
Publication date:
2002-08-05
DOI:
EISSN:
1535-4970
ISSN:
1073-449X
URN:
uuid:137c8331-8c60-4bf8-a112-3768ccfc5487
Source identifiers:
121945
Local pid:
pubs:121945

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