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Regulation and function of WASp in platelets by the collagen receptor, glycoprotein VI.

Abstract:

Wiskott Aldrich syndrome (WAS) is an X-linked recessive disorder associated with abnormalities in platelets and lymphocytes giving rise to thrombocytopenia and immunodeficiency. WAS is caused by a mutation in the gene encoding the cytoskeletal protein (WASp). Despite its importance, the role of WASp in platelet function is not established. WASp was recently shown to undergo tyrosine phosphorylation in platelets after activation by collagen, suggesting that it may play a selective role in acti...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
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Publisher:
W.B. Saunders
Journal:
Blood
Volume:
94
Issue:
12
Pages:
4166-4176
Publication date:
1999-12-05
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:137b9eed-db0b-416b-a582-2bf084368efe
Source identifiers:
66415
Local pid:
pubs:66415

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