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Journal article

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.

Abstract:

Myocardial infarction (MI), a leading cause of death around the world, displays a complex pattern of inheritance. When MI occurs early in life, genetic inheritance is a major component to risk. Previously, rare mutations in low-density lipoprotein (LDL) genes have been shown to contribute to MI risk in individual families, whereas common variants at more than 45 loci have been associated with MI risk in the population. Here we evaluate how rare mutations contribute to early-onset MI risk in t...

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Publisher copy:
10.1038/nature13917

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Journal:
Nature
Publication date:
2014-12-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
499832
Language:
English
Keywords:
Pubs id:
pubs:499832
UUID:
uuid:1373d5dc-8e71-4e5f-b5a1-c44eadcbcfb2
Local pid:
pubs:499832
Deposit date:
2015-01-05

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