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Ribosomal oxygenases are structurally conserved from prokaryotes to humans.

Abstract:

2-Oxoglutarate (2OG)-dependent oxygenases have important roles in the regulation of gene expression via demethylation of N-methylated chromatin components and in the hydroxylation of transcription factors and splicing factor proteins. Recently, 2OG-dependent oxygenases that catalyse hydroxylation of transfer RNA and ribosomal proteins have been shown to be important in translation relating to cellular growth, TH17-cell differentiation and translational accuracy. The finding that ribosomal oxy...

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Authors


Chowdhury, R More by this author
Sekirnik, R More by this author
Brissett, NC More by this author
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Journal:
Nature
Volume:
510
Issue:
7505
Pages:
422-426
Publication date:
2014
EISSN:
1476-4687
URN:
uuid:13734a6f-2918-433d-9ee8-b267a2f20ec1
Source identifiers:
477946
Local pid:
pubs:477946
Language:
English

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