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Imbalance between matrix metalloproteinase 9 and tissue inhibitor of metalloproteinases 1 expression by tumor cells implicated in liver metastasis from colorectal carcinoma.

Abstract:

We have evaluated the degree of MMP-9 and TIMP-1 messenger RNA (mRNA) expressions according to cell types in tumor tissues, and evaluated the implication of balance between the MMP-9 mRNA and the TIMP-1 mRNA expression in liver metastasis using orthotopic-implanted colon cancer in nude mouse, and also in 47 patients with colorectal cancer. The grade of MMP-9 or TIMP-1 mRNA expression was classified into 4 categories according to positive cell ratio. A higher grade of MMP-9 mRNA expression in ...

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Publisher copy:
10.2739/kurumemedj.48.211

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Shirouzu, K More by this author
Journal:
The Kurume medical journal
Volume:
48
Issue:
3
Pages:
211-218
Publication date:
2001
DOI:
EISSN:
1881-2090
ISSN:
0023-5679
URN:
uuid:136f320a-2cab-48d8-ba5a-34b9ea52dd50
Source identifiers:
226938
Local pid:
pubs:226938

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