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Increased expression of dysbindin-1A leads to a selective deficit in NMDA receptor signaling in the hippocampus

Abstract:

The effects of the major schizophrenia susceptibility gene disease DTNBP1 on disease risk are likely to be mediated through changes in expression level of the gene product, dysbindin-1. How such changes might influence pathogenesis is, however, unclear. One possible mechanism is suggested by recent work establishing a link between altered dysbindin-1 expression and changes in surface levels of N-methyl-d-aspartate receptors (NMDAR), although neither the precise nature of this relationship, no...

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Journal:
Neuropharmacology
Volume:
61
Issue:
8
Pages:
1345-1353
Publication date:
2011-12-01
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
Source identifiers:
194650
Language:
English
Keywords:
Pubs id:
pubs:194650
UUID:
uuid:13649768-ed3a-43e8-a95e-910a6c4de5f6
Local pid:
pubs:194650
Deposit date:
2012-12-19

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