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Dopamine release in the basal ganglia

Abstract:

Dopamine (DA) is a key transmitter in the basal ganglia, yet DA transmission does not conform to several aspects of the classic synaptic doctrine. Axonal DA release occurs through vesicular exocytosis and is action potential- and Ca 2+ -dependent. However, in addition to axonal release, DA neurons in midbrain exhibit somatodendritic release by an incompletely understood, but apparently exocytotic, mechanism. Even in striatum, axonal release sites are controversial, with evidence for DA varico...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Neuroscience
Volume:
198
Pages:
112-137
Publication date:
2011-12-15
DOI:
EISSN:
1873-7544
ISSN:
0306-4522
URN:
uuid:135f3a5f-21f1-4b1a-8d62-ae9b26b8e23f
Source identifiers:
216333
Local pid:
pubs:216333

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