The distribution of 5-HT(6) receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT(6) receptor antagonist [(125)I]SB-258585.

Journal article

We used the highly selective 5-HT(6) receptor radioligand [(125)I]SB-258585 (4-iodo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzene-sulfonamide) to perform autoradiographic binding studies on the rat brain. High levels of specific binding occurred in the corpus striatum, nucleus accumbens, Islands of Calleja and the olfactory tubercle. A high level of binding also appeared in the choroid plexus. Moderate levels occurred in several regions of the hippocampal formation and in certain regi...

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Authors: Roberts, J; Reavill, C; East, S; Harrison, P; Patel, S

• Publication status: Published
• Journal: Brain research
• Volume: 934
• Issue: 1
• Pages: 49-57
• Publication date: 2002-04-01
• DOI: 10.1016/s0006-8993(02)02360-0
• EISSN: 1872-6240
• ISSN: 0006-8993
• Language: English
• Keywords: Radioligand Assay; Brain; Autoradiography; Sympatholytics; Animals; Serotonin; Oxidopamine; Neural Pathways; Denervation; Iodine Radioisotopes; Male; Dopamine; Sulfonamides; Receptors, Serotonin; Neostriatum; Cerebrospinal Fluid; Rats, Sprague-Dawley; Binding Sites; Tyrosine 3-Monooxygenase; Serotonin Antagonists; Piperazines; Rats; Choroid Plexus; Neurons; Medial Forebrain Bundle; Substantia Nigra