- Abstract:
-
Cohesin's structural maintenance of chromosome 1 (Smc1) and Smc3 are rod-shaped proteins with 50-nm long intra-molecular coiled-coil arms with a heterodimerization domain at one end and an ABC-like nucleotide-binding domain (NBD) at the other. Heterodimerization creates V-shaped molecules with a hinge at their centre. Inter-connection of NBDs by Scc1 creates a tripartite ring within which, it is proposed, sister DNAs are entrapped. To investigate whether cohesin's hinge functions as a possibl...
Expand abstract - Publisher copy:
- 10.1038/emboj.2010.315
-
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- Journal:
- EMBO Journal
- Volume:
- 30
- Issue:
- 2
- Pages:
- 374-378
- Publication date:
- 2011-01-19
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- URN:
-
uuid:135d8bb7-e6ff-4e19-8e70-ccf17081f235
- Source identifiers:
-
115894
- Local pid:
- pubs:115894
- Copyright date:
- 2011
Journal article
A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion
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