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A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion

Abstract:

Cohesin's structural maintenance of chromosome 1 (Smc1) and Smc3 are rod-shaped proteins with 50-nm long intra-molecular coiled-coil arms with a heterodimerization domain at one end and an ABC-like nucleotide-binding domain (NBD) at the other. Heterodimerization creates V-shaped molecules with a hinge at their centre. Inter-connection of NBDs by Scc1 creates a tripartite ring within which, it is proposed, sister DNAs are entrapped. To investigate whether cohesin's hinge functions as a possibl...

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Publisher copy:
10.1038/emboj.2010.315

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Journal:
EMBO Journal
Volume:
30
Issue:
2
Pages:
374-378
Publication date:
2011-01-19
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:135d8bb7-e6ff-4e19-8e70-ccf17081f235
Source identifiers:
115894
Local pid:
pubs:115894
Language:
English
Keywords:

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