The expression and functions of toll-like receptors in atherosclerosis.

Journal article

Inflammation drives atherosclerosis. Both immune and resident vascular cell types are involved in the development of atherosclerotic lesions. The phenotype and function of these cells are key in determining the development of lesions. Toll-like receptors are the most characterised innate immune receptors and are responsible for the recognition of exogenous conserved motifs on pathogens, and, potentially, some endogenous molecules. Both endogenous and exogenous TLR agonists may be present in a...

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Authors: Cole, J; Georgiou, E; Monaco, C

• Publication status: Published
• Journal: Mediators of inflammation
• Volume: 2010
• Pages: 393946
• Publication date: 2010-01-01
• DOI: 10.1155/2010/393946
• EISSN: 1466-1861
• ISSN: 0962-9351
• Language: English
• Keywords: Monocytes; Humans; Antigen Presentation; Atherosclerosis; Macrophages; Mast Cells; T-Lymphocytes; Lymphocyte Activation; Dendritic Cells; Animals; Toll-Like Receptors