Journal article
Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: UK Heart and Renal Protection (UK HARP)-III. Rationale, trial design and baseline data
- Abstract:
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Background: Patients with chronic kidney disease (CKD) are at risk of progression to end-stage renal disease and cardiovascular disease. Data from other populations and animal experiments suggest that neprilysin inhibition (which augments the natriuretic peptide system) may reduce these risks, but clinical trials among patients with CKD are required to test this hypothesis.
Methods: UK Heart And Renal Protection (HARP)-III is a multicentre double-blind randomized controlled trial ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.1MB)
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- Publisher copy:
- 10.1093/ndt/gfw321
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Authors
Funding
Medical Research Council
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British Heart Foundation
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Cancer Research UK
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nephrology, Dialysis and Transplantation Journal website
- Volume:
- 32
- Issue:
- 12
- Pages:
- 2043-2051
- Publication date:
- 2016-09-17
- Acceptance date:
- 2016-07-14
- DOI:
- ISSN:
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0931-0509 and 1460-2385
- Source identifiers:
-
641818
Item Description
- Keywords:
- Pubs id:
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pubs:641818
- UUID:
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uuid:135a35a4-74a5-42b2-a8b7-a250c9c59ff6
- Local pid:
- pubs:641818
- Deposit date:
- 2016-09-09
Terms of use
- Copyright holder:
- © Haynes & Judge 2016
- Copyright date:
- 2016
- Notes:
- This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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