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Journal article

The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1.

Abstract:

Neurons transmit information at chemical synapses by releasing neurotransmitters that are stored in synaptic vesicles (SVs) at the presynaptic site. After release, these vesicles need to be efficiently retrieved in order to maintain synaptic transmission. In concurrence, malfunctions in SV recycling have been associated with cognitive disorders. Oligophrenin-1 (OPHN1) encodes a Rho-GTPase-activating protein (Rho-GAP) whose loss of function causes X-linked mental retardation. OPHN1 is highly e...

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Publication status:
Published

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Publisher copy:
10.1016/j.cub.2009.05.022

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Current biology : CB
Volume:
19
Issue:
13
Pages:
1133-1139
Publication date:
2009-07-01
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
Source identifiers:
185282

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