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Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia

Abstract:

Causes of the well-documented association between low levels of cognitive functioning and many adverse neuropsychiatric outcomes, poorer physical health and earlier death remain unknown. We used linkage disequilibrium regression and polygenic profile scoring to test for shared genetic aetiology between cognitive functions and neuropsychiatric disorders and physical health. Using information provided by many published genome-wide association study consortia, we created polygenic profile scores...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/mp.2015.225

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Wellcome Trust More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Molecular Psychiatry Journal website
Volume:
21
Issue:
11
Pages:
1624-1632
Publication date:
2016-01-26
Acceptance date:
2015-12-07
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
Pubs id:
pubs:598022
URN:
uri:133b3020-dc3f-4e84-8804-9680c70b76f9
UUID:
uuid:133b3020-dc3f-4e84-8804-9680c70b76f9
Local pid:
pubs:598022
Language:
English
Keywords:

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