- Abstract:
-
Causes of the well-documented association between low levels of cognitive functioning and many adverse neuropsychiatric outcomes, poorer physical health and earlier death remain unknown. We used linkage disequilibrium regression and polygenic profile scoring to test for shared genetic aetiology between cognitive functions and neuropsychiatric disorders and physical health. Using information provided by many published genome-wide association study consortia, we created polygenic profile scores...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 269.6KB)
-
- Publisher copy:
- 10.1038/mp.2015.225
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Molecular Psychiatry Journal website
- Volume:
- 21
- Issue:
- 11
- Pages:
- 1624-1632
- Publication date:
- 2016-01-26
- Acceptance date:
- 2015-12-07
- DOI:
- EISSN:
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1476-5578
- ISSN:
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1359-4184
- Pubs id:
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pubs:598022
- URN:
-
uri:133b3020-dc3f-4e84-8804-9680c70b76f9
- UUID:
-
uuid:133b3020-dc3f-4e84-8804-9680c70b76f9
- Local pid:
- pubs:598022
- Language:
- English
- Keywords:
- Copyright holder:
- Hagenaars, SP et al.
- Copyright date:
- 2016
- Notes:
- © The Authors 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Journal article
Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia
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