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Sputum microbiomic clustering in asthma and COPD reveals a Haemophilus‐predominant subgroup

Abstract:

Background:
Airway ecology is altered in asthma and chronic obstructive pulmonary disease (COPD). Anti‐microbial interventions might have benefit in subgroups of airway disease. Differences in sputum microbial profiles at acute exacerbation of airways disease are reflected by the γProteobacteria:Firmicutes (γP:F) ratio. We hypothesized that sputum microbiomic clusters exist in stable airways disease, which can be differentiated by the sputum γP:F ratio.


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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-5803-5121
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Publisher:
Wiley Publisher's website
Journal:
Allergy Journal website
Volume:
75
Issue:
4
Pages:
808-817
Publication date:
2019-09-25
Acceptance date:
2019-08-27
DOI:
EISSN:
1398-9995
ISSN:
0105-4538
Pmid:
31556120
Pubs id:
pubs:1063991
UUID:
uuid:13346dbf-2b01-4292-a010-7709061db921
Source identifiers:
1063991
Local pid:
pubs:1063991
Language:
English
Keywords:

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