- Abstract:
-
Background T-cell depleting strategies have become an integral part of immunosuppressive regimens in organ transplantation. Alemtuzumab is a humanized monoclonal antibody against CD52, a cell-surface antigen on several immune cells. It has been suggested that lymphocyte depletion increases the risk of serious infections. However, this has not been observed with short-term alemtuzumab treatment in an organ transplant setting. For induction therapy using alemtuzumab following l... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 1.2mb)
-
- Publisher copy:
- 10.1371/journal.pone.0161618
-
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- Grant:
- Bankhead-Coley Cancer Research Program (1BG-08)
- Grant:
- Grant-in-Aid for Young Scientists (B); grant number 15K19893
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 11
- Issue:
- 8
- Pages:
- Article: e0161618
- Publication date:
- 2016-08-25
- Acceptance date:
- 2016-08-09
- DOI:
- EISSN:
-
1932-6203
- Pubs id:
-
pubs:640609
- URN:
-
uri:1330ca83-7ff5-40e3-9ba9-ea05833d5dac
- UUID:
-
uuid:1330ca83-7ff5-40e3-9ba9-ea05833d5dac
- Local pid:
- pubs:640609
- Language:
- English
- Copyright holder:
- Hotta et al.
- Copyright date:
- 2016
- Notes:
-
© 2016 Hotta et al. This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. - License:
- CC BY
Journal article
CD52-Negative NK cells are abundant in the liver and less susceptible to alemtuzumab treatment
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