Journal article icon

Journal article

CD52-Negative NK cells are abundant in the liver and less susceptible to alemtuzumab treatment

Abstract:
Background T-cell depleting strategies have become an integral part of immunosuppressive regimens in organ transplantation. Alemtuzumab is a humanized monoclonal antibody against CD52, a cell-surface antigen on several immune cells. It has been suggested that lymphocyte depletion increases the risk of serious infections. However, this has not been observed with short-term alemtuzumab treatment in an organ transplant setting. For induction therapy using alemtuzumab following l... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0161618

Authors


More by this author
ORCID:
0000-0002-5433-5303
Matsuura, T More by this author
Muraoka, I More by this author
Tryphonopoulos, P More by this author
Expand authors...
More from this funder
Grant:
Bankhead-Coley Cancer Research Program (1BG-08)
More from this funder
Grant:
Grant-in-Aid for Young Scientists (B); grant number 15K19893
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
11
Issue:
8
Pages:
Article: e0161618
Publication date:
2016-08-25
Acceptance date:
2016-08-09
DOI:
EISSN:
1932-6203
Pubs id:
pubs:640609
URN:
uri:1330ca83-7ff5-40e3-9ba9-ea05833d5dac
UUID:
uuid:1330ca83-7ff5-40e3-9ba9-ea05833d5dac
Local pid:
pubs:640609
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP