- Abstract:
-
Levels of anti-inflammatory extracellular adenosine are controlled by the sequential action of the ectonucleotidases CD39 and CD73, whose expression in CD4(+) T cells has been associated with natural regulatory T cells (nTregs). We here show that CD73 expression on activated murine CD4(+) T cells is induced by TGF-β independently of Foxp3 expression, operates at the transcriptional level and translates into gain of functional capacity to generate adenosine. In the presence of AMP, CD73 induce...
Expand abstract - Publisher copy:
- 10.1002/eji.201141512
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- Journal:
- Eur J Immunol
- Volume:
- 41
- Issue:
- 10
- Pages:
- 2955-2965
- Publication date:
- 2011-10-05
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- URN:
-
uuid:13304800-5fb3-48d6-a10a-01cb09d3ef3a
- Source identifiers:
-
166496
- Local pid:
- pubs:166496
- Language:
- English
- Keywords:
- Copyright date:
- 2011
- Notes:
- PubMed ID: 21770045
Journal article
Generation of anti-inflammatory adenosine by leukocytes is regulated by TGF-β.
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