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Generation of anti-inflammatory adenosine by leukocytes is regulated by TGF-β.

Abstract:

Levels of anti-inflammatory extracellular adenosine are controlled by the sequential action of the ectonucleotidases CD39 and CD73, whose expression in CD4(+) T cells has been associated with natural regulatory T cells (nTregs). We here show that CD73 expression on activated murine CD4(+) T cells is induced by TGF-β independently of Foxp3 expression, operates at the transcriptional level and translates into gain of functional capacity to generate adenosine. In the presence of AMP, CD73 induce...

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Publisher copy:
10.1002/eji.201141512

Authors


Regateiro, FS More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Agorogiannis, EI More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
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Journal:
Eur J Immunol
Volume:
41
Issue:
10
Pages:
2955-2965
Publication date:
2011-10-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:13304800-5fb3-48d6-a10a-01cb09d3ef3a
Source identifiers:
166496
Local pid:
pubs:166496

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