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Generation of anti-inflammatory adenosine by leukocytes is regulated by TGF-β.

Abstract:

Levels of anti-inflammatory extracellular adenosine are controlled by the sequential action of the ectonucleotidases CD39 and CD73, whose expression in CD4(+) T cells has been associated with natural regulatory T cells (nTregs). We here show that CD73 expression on activated murine CD4(+) T cells is induced by TGF-β independently of Foxp3 expression, operates at the transcriptional level and translates into gain of functional capacity to generate adenosine. In the presence of AMP, CD73 induce...

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Publisher copy:
10.1002/eji.201141512

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
Eur J Immunol
Volume:
41
Issue:
10
Pages:
2955-2965
Place of publication:
Germany
Publication date:
2011-10-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
166496

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