Journal article
Structural analyses on intermediates in serine protease catalysis.
- Abstract:
-
Although the subject of many studies, detailed structural information on aspects of the catalytic cycle of serine proteases is lacking. Crystallographic analyses were performed in which an acyl-enzyme complex, formed from elastase and a peptide, was reacted with a series of nucleophilic dipeptides. Multiple analyses led to electron density maps consistent with the formation of a tetrahedral species. In certain cases, apparent peptide bond formation at the active site was observed, and the ele...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m600495200
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Authors
Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 281
- Issue:
- 33
- Pages:
- 24024-24035
- Publication date:
- 2006-08-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
40101
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:40101
- UUID:
-
uuid:132f70bf-77a7-4812-8225-db5e9eb05cbf
- Local pid:
- pubs:40101
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2006
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