Journal article icon

Journal article

Structural analyses on intermediates in serine protease catalysis.

Abstract:

Although the subject of many studies, detailed structural information on aspects of the catalytic cycle of serine proteases is lacking. Crystallographic analyses were performed in which an acyl-enzyme complex, formed from elastase and a peptide, was reacted with a series of nucleophilic dipeptides. Multiple analyses led to electron density maps consistent with the formation of a tetrahedral species. In certain cases, apparent peptide bond formation at the active site was observed, and the ele...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.m600495200

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Journal of biological chemistry
Volume:
281
Issue:
33
Pages:
24024-24035
Publication date:
2006-08-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
40101
Language:
English
Keywords:
Pubs id:
pubs:40101
UUID:
uuid:132f70bf-77a7-4812-8225-db5e9eb05cbf
Local pid:
pubs:40101
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP