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Detailed interrogation of trypanosome cell biology via differential organelle staining and automated image analysis.

Abstract:

BACKGROUND: Many trypanosomatid protozoa are important human or animal pathogens. The well defined morphology and precisely choreographed division of trypanosomatid cells makes morphological analysis a powerful tool for analyzing the effect of mutations, chemical insults and changes between lifecycle stages. High-throughput image analysis of micrographs has the potential to accelerate collection of quantitative morphological data. Trypanosomatid cells have two large DNA-containing organelles...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1186/1741-7007-10-1

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Wellcome Trust More from this funder
E. P. Abraham Trust More from this funder
Engineering and Physical Sciences Research Council More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC biology Journal website
Volume:
10
Issue:
1
Pages:
1
Publication date:
2012-01-03
DOI:
EISSN:
1741-7007
ISSN:
1741-7007
Source identifiers:
222369

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