Journal article
Specific amino acids of the glycosyltransferase LpsA direct the addition of glucose or galactose to the terminal inner core heptose of Haemophilus influenzae lipopolysaccharide via alternative linkages.
- Abstract:
-
Lipopolysaccharide is the major glycolipid of the cell wall of the bacterium Haemophilus influenzae, a Gram-negative commensal and pathogen of humans. Lipopolysaccharide is both a virulence determinant and a target for host immune responses. Glycosyltransferases have high donor and acceptor substrate specificities that are generally limited to catalysis of one unique glycosidic linkage. The H. influenzae glycosyltransferase LpsA is responsible for the addition of a hexose to the distal heptos...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m604908200
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Bibliographic Details
- Journal:
- The Journal of biological chemistry
- Volume:
- 281
- Issue:
- 40
- Pages:
- 29455-29467
- Publication date:
- 2006-10-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:132c6e8a-6be2-460e-ba3f-5404d784c4bd
- Source identifiers:
-
115598
- Local pid:
- pubs:115598
Item Description
Terms of use
- Copyright date:
- 2006
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