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Journal article

Specific amino acids of the glycosyltransferase LpsA direct the addition of glucose or galactose to the terminal inner core heptose of Haemophilus influenzae lipopolysaccharide via alternative linkages.

Abstract:

Lipopolysaccharide is the major glycolipid of the cell wall of the bacterium Haemophilus influenzae, a Gram-negative commensal and pathogen of humans. Lipopolysaccharide is both a virulence determinant and a target for host immune responses. Glycosyltransferases have high donor and acceptor substrate specificities that are generally limited to catalysis of one unique glycosidic linkage. The H. influenzae glycosyltransferase LpsA is responsible for the addition of a hexose to the distal heptos...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m604908200

Authors


Deadman, ME More by this author
Lundström, SL More by this author
Schweda, EK More by this author
Journal:
The Journal of biological chemistry
Volume:
281
Issue:
40
Pages:
29455-29467
Publication date:
2006-10-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:132c6e8a-6be2-460e-ba3f-5404d784c4bd
Source identifiers:
115598
Local pid:
pubs:115598

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