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The unusual mycobacterial chaperonins: evidence for in vivo oligomerization and specialization of function.

Abstract:

The pathogen Mycobacterium tuberculosis expresses two chaperonins, one (Cpn60.1) dispensable and one (Cpn60.2) essential. These proteins have been reported not to form oligomers despite the fact that oligomerization of chaperonins is regarded as essential for their function. We show here that the Cpn60.2 homologue from Mycobacterium smegmatis also fails to oligomerize under standard conditions. However, we also show that the Cpn60.2 proteins from both organisms can replace the essential groEL...

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Publication status:
Published

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Journal:
Molecular microbiology
Volume:
85
Issue:
5
Pages:
934-944
Publication date:
2012-09-05
DOI:
EISSN:
1365-2958
ISSN:
0950-382X
URN:
uuid:13224517-a920-40a8-98b5-7f89105bd526
Source identifiers:
350865
Local pid:
pubs:350865

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