Journal article
PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation
- Abstract:
-
Recruitment of the Polycomb repressive complexes PRC1 and PRC2 by Xist RNA is an important paradigm for chromatin regulation by long non-coding RNAs. Here we show that the non-canonical PCGF3/5-PRC1 complex initiates recruitment of both PRC1 and PRC2 in response to Xist RNA expression. PCGF3/5-PRC1 mediated ubiquitylation of histone H2A signals recruitment of other non-canonical PRC1 complexes, and of PRC2, leading to deposition of histone H3 lysine 27 methylation chromosome wide. Pcgf3/5 gen...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 3.1MB)
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(Accepted manuscript, pdf, 319.5KB)
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(Accepted manuscript, pdf, 2.0MB)
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(Accepted manuscript, pdf, 3.6MB)
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(Accepted manuscript, pdf, 3.2MB)
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(Accepted manuscript, pdf, 431.8KB)
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- Publisher copy:
- 10.1126/science.aal2512
Authors
Funding
+ Fundação para a
Ciência e Tecnologia, Portugal
More from this funder
Funding agency for:
Almeida, M
Grant:
SFRH/BD/51706/2011
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Journal website
- Volume:
- 356
- Issue:
- 6342
- Pages:
- 1081-1084
- Publication date:
- 2017-06-09
- Acceptance date:
- 2017-05-12
- DOI:
- EISSN:
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1095-9203
- ISSN:
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0036-8075
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:697911
- UUID:
-
uuid:132032ac-36e3-464f-9fe1-94ee7de7de87
- Local pid:
- pubs:697911
- Source identifiers:
-
697911
- Deposit date:
- 2017-06-01
Terms of use
- Copyright holder:
- American Association for the Advancement of Science
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 American Association for the Advancement of Science. This is the accepted manuscript version of the article. The final version is available online from American Association for the Advancement of Science at: https://doi.org/10.1126/science.aal2512
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