- Abstract:
-
G protein-coupled receptor 40 (GPR40)/free fatty acid 1 (FFA1) is a G protein-coupled receptor involved in free fatty acid-induced insulin secretion. To analyze the effect of our novel GPR40/FFA1-selective agonist, [(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid hemi-hydrate (TAK-875), on insulin and glucagon secretion, we performed hormone secretion assays and measured intracellular Ca²⁺ concentration ([Ca²⁺](i)) in both...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1124/jpet.111.187708
-
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- Journal:
- The Journal of pharmacology and experimental therapeutics
- Volume:
- 340
- Issue:
- 2
- Pages:
- 483-489
- Publication date:
- 2012-02-05
- DOI:
- EISSN:
-
1521-0103
- ISSN:
-
0022-3565
- URN:
-
uuid:13163578-458b-4622-9af4-4b6b43d39912
- Source identifiers:
-
206075
- Local pid:
- pubs:206075
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets.
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