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The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets.

Abstract:

G protein-coupled receptor 40 (GPR40)/free fatty acid 1 (FFA1) is a G protein-coupled receptor involved in free fatty acid-induced insulin secretion. To analyze the effect of our novel GPR40/FFA1-selective agonist, [(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid hemi-hydrate (TAK-875), on insulin and glucagon secretion, we performed hormone secretion assays and measured intracellular Ca²⁺ concentration ([Ca²⁺](i)) in both...

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Publication status:
Published

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Publisher copy:
10.1124/jpet.111.187708

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
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Journal:
The Journal of pharmacology and experimental therapeutics
Volume:
340
Issue:
2
Pages:
483-489
Publication date:
2012-02-05
DOI:
EISSN:
1521-0103
ISSN:
0022-3565
URN:
uuid:13163578-458b-4622-9af4-4b6b43d39912
Source identifiers:
206075
Local pid:
pubs:206075

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