Epigenetic regulation in the pathophysiology of Alzheimer's disease.

Journal article

With the aging of the population, the growing incidence and prevalence of Alzheimer's disease (AD) increases the burden on individuals and society as a whole. To date, the pathophysiology of AD is not yet fully understood. Recent studies have suggested that epigenetic mechanisms may play a pivotal role in its course and development. The most frequently studied epigenetic mechanisms are DNA methylation and histone modifications, and investigations relevant to aging and AD are presented in this...

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Authors: Chouliaras, L; Rutten, B; Kenis, G; Peerbooms, O; Visser, P

• Journal: Progress in neurobiology
• Volume: 90
• Issue: 4
• Pages: 498-510
• Publication date: 2010-04-01
• DOI: 10.1016/j.pneurobio.2010.01.002
• EISSN: 1873-5118
• ISSN: 0301-0082
• Language: English
• Keywords: DNA Methylation; Humans; Genetic Predisposition to Disease; Alzheimer Disease; Animals; Histones; Environment; Gene Expression Regulation; Aging; Epigenesis, Genetic