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Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines.

Abstract:

The effect of vascular endothelial growth factor (VEGF) ligands and cediranib on tumor cell proliferation, migration, and invasion was determined. It has recently been suggested that autocrine signaling through the VEGF receptor (VEGFR) pathway may play a role in tumor cell survival, invasion, and migration. The purpose of the present study was to determine the expression of VEGFRs and VEGFR ligands in a panel of gastrointestinal carcinoma cells. Additionally, we evaluated the effects of VEGF...

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Publication status:
Published

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Authors


Morelli, MP More by this author
Tentler, JJ More by this author
Ciardiello, F More by this author
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Journal:
Molecular cancer therapeutics
Volume:
8
Issue:
9
Pages:
2546-2558
Publication date:
2009-09-05
DOI:
EISSN:
1538-8514
ISSN:
1535-7163
URN:
uuid:13125545-2ef4-4f99-9753-c1eb4fb5e5a7
Source identifiers:
312671
Local pid:
pubs:312671

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