e-Lung computed tomography biomarkers are associated with outcomes in fibrotic interstitial lung diseases

Journal article

BackgroundThe e-Lung weighted reticulovascular score (WRVS) is an automated computed tomography biomarker that quantifies interstitial lung disease (ILD) severity and is associated with prognosis in patients with idiopathic pulmonary fibrosis (IPF). The aims of the present study were to evaluate WRVS as a prognostic factor in patients with non-IPF ILD.MethodsThe test cohort comprised patients from the Open Source Imaging Consortium and the validation cohort, patients recruited to the prospective German CoWorker ILD registry. Associations between baseline and serial WRVS with future forced vital capacity (FVC) decline and survival were tested.ResultsMedian survival was 7.1 and 6.1 years in the test (n=302) and validation (n=378) cohorts, respectively. Baseline WRVS was associated with mortality in test (hazard ratio (HR) 1.11, 95% CI 1.08-1.14; pConclusionIn patients with non-IPF ILD, the e-Lung WRVS biomarker is associated with mortality and FVC decline when applied to baseline high-resolution computed tomography scans replicating previous studies in IPF. Patients with an increase in WRVS of 3% on serial computed tomography scans have significantly increased risk of mortality.

Authors: Abbasi Dezfouli, K; Devaraj, A; Ottink, FA; Rennison-Jones, C; Sifostratoudaki, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: European Respiratory Society
• Journal: ERJ Open Research
• Volume: 12
• Issue: 3
• Pages: 1058-2025
• Publication date: 2026-05-26
• Acceptance date: 2025-10-29
• DOI: 10.1183/23120541.01058-2025
• EISSN: 2312-0541
• ISSN: 2312-0541
• Pmid: 42206014
• Language: English
• Keywords: Biomarker; Cohort; Interstitial lung disease; Imaging biomarker; Idiopathic pulmonary fibrosis; Vital capacity; Prospective cohort study; Lung; Cohort study