Germline APC mutations are not commonly seen in children with sporadic hepatoblastoma.

Journal article

Hepatoblastoma is the most common primary liver tumor in childhood and occurs more commonly in families with familial adenomatous polyposis. Germline mutations of the gene responsible for familial adenomatous polyposis--adenomatous polyposis coli (APC)--are described in patients with hepatoblastoma even without a family history. We investigated children presenting with apparently sporadic hepatoblastoma between 1991 and 2004. Blood samples were available from 29 children (18 boys) whose condi...

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Authors: Harvey, J; Clark, S; Hyer, W; Hadzic, N; Tomlinson, I

• Journal: Journal of pediatric gastroenterology and nutrition
• Volume: 47
• Issue: 5
• Pages: 675-677
• Publication date: 2008-11-01
• DOI: 10.1097/mpg.0b013e318174e808
• EISSN: 1536-4801
• ISSN: 0277-2116
• Language: English
• Keywords: Child; Child, Preschool; Liver Neoplasms; Infant; Polymorphism, Single Nucleotide; Germ-Line Mutation; Genes, APC; Female; Male; Prevalence; Base Sequence; Humans; Adenomatous Polyposis Coli; Hepatoblastoma; Retrospective Studies; DNA Primers