Journal article
The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies
- Abstract:
-
Background Amplifying endogenous neuroprotective mechanisms is a promising avenue for stroke therapy. One target is mammalian target of rapamycin (mTOR), a serine/threonine kinase regulating cell proliferation, cell survival, protein synthesis, and autophagy. Animal studies investigating the effect of rapamycin on mTOR inhibition following cerebral ischemia have shown conflicting results. Aim To conduct a systematic review and meta-analysis evaluating the ef... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Medical Research Council
More from this funder
Funding agency for:
Beard, D
Buchan, A
Grant:
MR/M022757/1
MR/M022757/1
+ Oxford University Clinical Academic Graduate School
More from this funder
Funding agency for:
Hadley, G
Bibliographic Details
- Publisher:
- Sage Publications Publisher's website
- Journal:
- International Journal of Stroke Journal website
- Volume:
- 14
- Issue:
- 2
- Pages:
- 137-145
- Publication date:
- 2018-11-29
- Acceptance date:
- 2018-09-23
- DOI:
- EISSN:
-
1747-4949
- ISSN:
-
1747-4930
Item Description
- Keywords:
- Pubs id:
-
pubs:923400
- UUID:
-
uuid:12fde5ef-ec29-442e-9887-e242e09a1524
- Local pid:
- pubs:923400
- Source identifiers:
-
923400
- Deposit date:
- 2018-10-04
Terms of use
- Copyright holder:
- World Stroke Organization
- Copyright date:
- 2018
- Notes:
- ©️ 2018 World Stroke Organization. This is the accepted manuscript version of the article. The final version is available online from SAGE Publications at: 10.1177/1747493018816503
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