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Journal article

ASYMMETRIC-SYNTHESIS OF (-)-(1R,2S)-CISPENTACIN AND RELATED CIS-2-AMINO AND TRANS-2-AMINO CYCLOPENTANE-1-CARBOXYLIC AND CYCLOHEXANE-1-CARBOXYLIC ACIDS

Abstract:
The antifungal antibiotic (-)-(1R,2S)-2-aminocyclopentane-1-carboxylic acid (cispentacin) 8 and its cyclohexane homologue 14 have been prepared utilizing the highly stereoselective conjugate addition of homochiral lithium N-benzyl-N-α-methylbenzylamide 5. The corresponding trans-β-amino acids 10 and 16 were also prepared via the selective epimerization of the cis-β-amino ester conjugate addition products.
Publication status:
Published

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Publisher copy:
10.1039/p19940001411

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
Issue:
11
Pages:
1411-1415
Publication date:
1994-06-07
DOI:
EISSN:
1364-5463
ISSN:
0300-922X
Pubs id:
pubs:110866
UUID:
uuid:12f58856-2f2c-4ab1-9e18-2b5df9dc9e12
Local pid:
pubs:110866
Source identifiers:
110866
Deposit date:
2012-12-19

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