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Calculation of carcinogenic potency from long-term animal carcinogenesis experiments.

Abstract:

An index of carcinogenic potency for chemicals tested in chronic animal experiments is described. By analogy with the well-known 'lethal dose 50' (LD50) of quantal bioassay, a 'tumorigenic dose 50' (TD50) may be defined (in the absence both of tumors in the control group and of intercurrent deaths) as that (daily) dose of chemical which gives 50% of the test animals tumors by some fixed age. Tumors in the control (zero-dose) group are handled exactly as for the LD50, and intercurrent deaths a...

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Publication status:
Published

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Publisher copy:
10.2307/2530741

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Role:
Author
Journal:
Biometrics
Volume:
40
Issue:
1
Pages:
27-40
Publication date:
1984-03-05
DOI:
EISSN:
1541-0420
ISSN:
0006-341X
URN:
uuid:12f492e1-f94a-439b-b4b1-c5a8bf4c9f93
Source identifiers:
42314
Local pid:
pubs:42314

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