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Journal article

Self reporting RNA probes as an alternative to cleavable small molecule mass tags.

Abstract:

The large size of biological molecules such as proteins and oligonucleotides makes them inherently problematic to analyse and quantify directly by mass spectrometry. For these molecules, electrospray ionisation produces multiply charged species and associated alkali metal adducts which can reduce sensitivity and complicate quantification. Whereas time-of-flight mass analysers, often coupled to matrix-assisted laser desorption/ionisation, can have insufficient mass resolution to resolve these ...

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Publication status:
Published

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Publisher copy:
10.1039/c2an36086a

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Analyst
Volume:
137
Issue:
24
Pages:
5817-5822
Publication date:
2012-12-01
DOI:
EISSN:
1364-5528
ISSN:
0003-2654
Source identifiers:
399973
Language:
English
Keywords:
Pubs id:
pubs:399973
UUID:
uuid:12f291ba-2c7a-4ce4-ad9e-99256e1be684
Local pid:
pubs:399973
Deposit date:
2013-11-16

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