Chemical aspects of clustered DNA damage induction by ionising radiation.

Journal article

Ionising radiation induces a variety of chemical modifications to DNA, ranging from simple, isolated lesions to clustered DNA damage, in which two or more lesions are formed within a few tens of base pairs by a single radiation track. Multiple lesions, e.g. tandem lesions and amplification of damage, may also be induced in DNA by reaction with a single hydroxyl radical. It has been proposed from biophysical modelling that clustered DNA damage is less repairable and therefore contributes to th...

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Authors: Lomax, M; Gulston, M; O'Neill, P

• Publication status: Published
• Journal: Radiation protection dosimetry
• Volume: 99
• Issue: 1-4
• Pages: 63-68
• Publication date: 2002-01-01
• DOI: 10.1093/oxfordjournals.rpd.a006840
• EISSN: 1742-3406
• ISSN: 0144-8420
• Language: English
• Keywords: Hydroxyl Radical; DNA Damage; DNA Glycosylases; Cells, Cultured; Radiation, Ionizing; DNA; Mammals; N-Glycosyl Hydrolases; Animals