- Abstract:
-
Lon and m-AAA are the principal, regulated proteases required for protein maturation and turnover in the mitochondrial matrix of diverse species. To understand their roles in fission yeast (Schizosaccharomyces pombe) mitochondria, we generated deletion strains lacking Lon and m-AAA, individually (Δlon1 and Δm-AAA) or together, Δlon1Δm-AAA (Δ/Δ). All three strains were viable but incapable of respiratory growth on a non-fermentable carbon source due to mitochondrial dysfunction. Confocal and e...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.jmb.2011.02.044
-
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- Journal:
- Journal of molecular biology
- Volume:
- 408
- Issue:
- 2
- Pages:
- 222-237
- Publication date:
- 2011-04-05
- DOI:
- EISSN:
-
1089-8638
- ISSN:
-
0022-2836
- URN:
-
uuid:12e6dcbb-6b1a-4349-b152-e443ca1046ba
- Source identifiers:
-
120182
- Local pid:
- pubs:120182
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Transcriptional and cellular responses to defective mitochondrial proteolysis in fission yeast.
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