Journal article icon

Journal article

Transcriptional and cellular responses to defective mitochondrial proteolysis in fission yeast.

Abstract:

Lon and m-AAA are the principal, regulated proteases required for protein maturation and turnover in the mitochondrial matrix of diverse species. To understand their roles in fission yeast (Schizosaccharomyces pombe) mitochondria, we generated deletion strains lacking Lon and m-AAA, individually (Δlon1 and Δm-AAA) or together, Δlon1Δm-AAA (Δ/Δ). All three strains were viable but incapable of respiratory growth on a non-fermentable carbon source due to mitochondrial dysfunction. Confocal and e...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.jmb.2011.02.044

Authors


López-Maury, L More by this author
Bähler, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Expand authors...
Journal:
Journal of molecular biology
Volume:
408
Issue:
2
Pages:
222-237
Publication date:
2011-04-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:12e6dcbb-6b1a-4349-b152-e443ca1046ba
Source identifiers:
120182
Local pid:
pubs:120182

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP