Charade of the SR K+-channel: two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel.

Journal article

The presence of a sarcoplasmic reticulum (SR) K+-selective ion-channel has been known for >30 years yet the molecular identity of this channel has remained a mystery. Recently, an SR trimeric intracellular cation channel (TRIC-A) was identified but it did not exhibit all expected characteristics of the SR K+-channel. We show that a related SR protein, TRIC-B, also behaves as a cation-selective ion-channel. Comparison of the single-channel properties of purified TRIC-A and TRIC-B in symmetr...

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Authors: Pitt, S; Park, K; Nishi, M; Urashima, T; Aoki, S

• Publication status: Published
• Journal: Biophysical journal
• Volume: 99
• Issue: 2
• Pages: 417-426
• Publication date: 2010-07-01
• DOI: 10.1016/j.bpj.2010.04.051
• EISSN: 1542-0086
• ISSN: 0006-3495
• Language: English
• Keywords: Cell Membrane Permeability; Animals; Calcium; Potassium Channels; Muscle, Skeletal; Electric Conductivity; Potassium Chloride; Myocardium; Sarcoplasmic Reticulum; Sheep; Rabbits; Ion Channel Gating