Journal article
Premature sister chromatid separation is poorly detected by the spindle assembly checkpoint as a result of system-level feedback
- Abstract:
-
Sister chromatid cohesion, mediated by the cohesin complex, is essential for faithful mitosis. Nevertheless, evidence suggests that the surveillance mechanism that governs mitotic fidelity, the spindle assembly checkpoint (SAC), is not robust enough to halt cell division when cohesion loss occurs prematurely. The mechanism behind this poor response is not properly understood. Using developing Drosophila brains, we show that full sister chromatid separation elicits a weak checkpoint response r...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ Engineering and Physical Sciences Research Council
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Funding agency for:
Hutter, L
Grant:
G0601617
European Commission
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Biotechnology and Biological Sciences Research Council
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Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 13
- Issue:
- 3
- Pages:
- 469–478
- Publication date:
- 2015-10-01
- DOI:
- ISSN:
-
2211-1247
Item Description
- Pubs id:
-
pubs:575156
- UUID:
-
uuid:12e3cdbf-d416-4006-867e-792a0c1d5cb1
- Local pid:
- pubs:575156
- Source identifiers:
-
575156
- Deposit date:
- 2015-11-25
Terms of use
- Copyright holder:
- Mirkovic et al
- Copyright date:
- 2015
- Notes:
- Copyright © 2015 The Authors. Under a Creative Commons license.
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