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Thymic epithelial cell support of thymopoiesis does not require Klotho

Abstract:

Age-related thymic involution is characterized by a decrease in thymic epithelial cell (TEC) number and function parallel to a disruption in their spatial organization, resulting in defective thymocyte development and proliferation as well as peripheral T cell dysfunction. Deficiency of Klotho, an antiaging gene and modifier of fibroblast growth factor signaling, causes premature aging. To investigate the role of Klotho in accelerated age-dependent thymic involution, we conducted a comprehens...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1800670

Authors


McElmurry, RT More by this author
Parker, SL More by this author
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Children’s’ Cancer Research Fund More from this funder
Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
201
Issue:
11
Pages:
3320-3328
Publication date:
2018-10-29
Acceptance date:
2018-09-28
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pubs id:
pubs:927657
URN:
uri:12e22a83-b975-4753-adfb-64ec78ea241a
UUID:
uuid:12e22a83-b975-4753-adfb-64ec78ea241a
Local pid:
pubs:927657

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